1H-indazole-3-carboxylic acid, methyl ester

1H-indazole-3-carboxylic acid, methyl ester - Names and Identifiers

Name	Methyl 1H-indazole-3-carboxylate
Synonyms	TIMTEC-BB SBB009999 Methyl 1H-indazole-3-carb... METHYL INDAZOLYL-3-CARBOXYLATE Methyl 1H-indazole-3-carboxylate 3-Indazolecarboxylic acid methyl ester Indazole-3-carboxylic Acid Methyl Ester 1H-Indazole-3-Carboxylic Acid Methyl Ester 1H-INDAZOLE-3-CARBOXYLIC ACID METHYL ESTER 1H-indazole-3-carboxylic acid, methyl ester 1H-Indazole-3-Carboxylic Acid Methyl Ester(WX6
CAS	43120-28-1
InChI	InChI=1/C9H8N2O2/c1-13-9(12)8-6-4-2-3-5-7(6)10-11-8/h2-5H,1H3,(H,10,11)

1H-indazole-3-carboxylic acid, methyl ester - Physico-chemical Properties

Molecular Formula	C9H8N2O2
Molar Mass	176.17
Density	1.324
Melting Point	162-163℃
Boling Point	345.2±15.0 °C(Predicted)
Flash Point	162.6°C
Solubility	Chloroform (Slightly), Methanol (Slightly)
Vapor Presure	6.24E-05mmHg at 25°C
Appearance	Solid
Color	White to Off-White
pKa	11.93±0.40(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.648

1H-indazole-3-carboxylic acid, methyl ester - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed
WGK Germany	3

1H-indazole-3-carboxylic acid, methyl ester - Introduction

Methyl 1H-indazole-3-carboxylate(Methyl 1H-indazole-3-carboxylate) is an organic compound with the chemical formula C10H8N2O2.

Nature:
Methyl 1H-indazole-3-carboxylate is a colorless to pale yellow liquid with a low boiling point and melting point. It is soluble in organic solvents such as acetonitrile, dichloromethane and ethanol, but insoluble in water.

Use:
Methyl 1H-indazole-3-carboxylate has important applications in the field of drug synthesis and organic synthesis. It is a key intermediate for the synthesis of many drugs, such as anti-cancer drugs, anti-inflammatory drugs and antidepressants.

Preparation Method:
Methyl 1H-indazole-3-carboxylate can be prepared by a variety of synthetic methods. The more common method is to react indazole-3-carboxylic acid with methanol under acid catalysis. A specific procedure involves reacting indazole-3-carboxylic acid with a small amount of an acid such as sulfuric acid or hydrochloric acid and methanol at an appropriate temperature for a period of time and then purifying the product by distillation.

Safety Information:
Methyl 1H-indazole-3-carboxylate is generally considered to be relatively safe under correct operating conditions. But as a chemical, should comply with the general laboratory safety practices. It may be irritating to the eyes, skin and respiratory system, so personal protective equipment such as laboratory gloves, protective glasses and laboratory coats should be worn during operation. Ingestion and inhalation should be avoided. In case of inadvertent contact, flush the affected area immediately with plenty of water and seek prompt medical help.

Last Update：2024-04-09 21:11:58